Protein Folding, or how to predict the 3D structure of proteins from 1D sequence, is a key task in molecular biology which is not yet resolved.
Folding@home is an oldest citizen science project i know. The project has started in October 2000 and now approaches its 20th anniversary.
Anyone can fold at home with a personal computer. The Folding@home software will run in the background, eat some free resources and fold the proteins for several projects including Oncology and COVID-19.
It does not slow down my laptop as i writing this post running The Folding@home in the background.
Software installation is here: https://foldingathome.org/start-folding/
Scientific part & publications of results: https://foldingathome.org/category/science/
Competing (donating resources) teams: https://stats.foldingathome.org/teams